The prototype
What makes Lynchburg interesting for me is that there were three major railroads and a lot of history in a small space. In order of appearance, there was Southern, N&W, and C&O, all of which shared a Union Station and track right downtown on the James River. Lynchburg is located on Southern's original main line between Washington and Atlanta, just a few miles south of Monroe (a crew change point, and where Steve Brody of Old 97 fame went on duty). It is also on the N&W's main line between Roanoke and Norfolk. I know less about the C&O, but I believe the line up the James River was a major one for them as well.
Southern was first, with the line from the north (the Orange & Alexandria) being in place before the Civil War. The line to the south (Lynchburg & Danville) was built in the early 1870s. The old main line came down into the James River Valley, crossed the river, there was a yard on the river, and then the line climbed and twisted its way back up out of the valley and went on south. The main line went through the Jefferson St. tunnel right down town, and did so until it was finally rerouted in the late 1970s or early '80s. About 1911, a new double track main line was built which completely bypassed the valley, downtown, Union Station, and the Jefferson St. tunnel (although it too went through a tunnel before crossing the river). The new main line crosses the river on an impressive steel bridge. The old main line north of Lynchburg was abandoned in 1937, but the south portion is still in service today as an interchange between NS and CSX.
The N&W came through before the Civil War as well, and line Southern it dropped down into the valley, crossed the river, and then climbed back out the other side. The old main line went through a yard which was on Percival Island in the middle of the James River. The N&W also had a line which ran south, from Lynchburg to Durham, NC. Also around 1910, the N&W built a new main line to avoid the steep grades into and out of the valley. The original main line was in use into the 1960s at least, and Percival Island today is a walking trail, with the bridges at either end of the island still intact.
With the construction of the new Southern & N&W main lines, a pair of new yards and a double wye were built to connect them, and those yards are in use today as NS's Montview and Kinney yards, under the control of a single yardmaster.
I know less about the C&O, but I do know that, unlike the other two, it came unto Lynchburg up the James River, and therefore had no severe grades to deal with. The line follws the river bank for many miles. Though they are gone today, at one time both Southern and N&W crossed the C&O main line at grade in Lynchburg.
In addition to the three major main lines, there were a number of branches, spurs, etc, all of which seemed to be so interwoven as to tie themselves in knots. Take a trip on the old Southern main line, and you'll see tracks going along side, over, and under, with a number of interesting bridges all over the place. I can only imagine what the place would have been line in its heyday, with named trains running on all three railroads, and a number of locals, yard jobs, and switchers running around switching the industries in the area.