Some Follow-up Comments
Matt, I'll throw in a couple other comments at this point. Please be aware that the things I've written are based on industrial/commercial ventilation for spray booths, and I've yet to see a hobby booth that meets all these requirements.
For example, a spray booth would be designed with the first concern being the velocity of the air entering the opening in the booth. A small booth with an open area of under 4 square feet would ideally have an air volume of 200 CFM per square foot flowing across it's open face in order to achieve the required velocity. A larger face area could get by at perhaps 150 CFM/SF. So, suppose you had an opening that measured 24" wide x 18" high. That would be 3 square feet. 3 SF x 200 CFM = 600 CFM of airflow. How many hobby booths come even remotely close to this? Obviously we hobbyists are going to use something considerably less, and we won't be achieving "industrial grade" ventilation. OSHA wouldn't be happy with us. So we start right off the bat with a huge compromise.
The next thing is to decide how big the filter has to be. And here comes the next big compromise. Filters for "legitimate" spray booths are specifically designed for this application. As hobbyists, we're either using some "combination" filter offered by the hobbyist spray booth manufacturer, or for DIY builders, a filter designed for household use. Those filters vary all over the place in how effective they will be in this application, and you won't find any specs that state how they rate in removing paint particles from the air stream. And that's because they aren't tested and rated for that. So you're strictly shooting from the hip there. In general, the larger the face area of the filter, the more effective it will be at a given air flow. Slow the air down moving through the filter, the more efficient it becomes in removing what ever it's rated to remove. Generally, you want to move air through the filter at a velocity rate of 100-500 feet per minute. You've probably seen household air filters with general ratings for removing dust, pollen, smoke, etc. And those are some pretty good guidelines within a given brand. But there is a trade-off there. The better the filter is at removing contaminants, the higher it's static pressure drop. Sooo, a more powerful blower is required to maintain the air flow you require. The thinner, less expensive filters are mostly a waste of effort, as they aren't very efficient, and don't remove much beyond coarse dust. And one other thing about filters to remember: as the filter becomes dirty, it's resistance to air flow increases (the static pressure drop goes up). The dirtier the filter, the less air flow through it. A dirty air filter can more than double it's SP drop.
There are other considerations in the dimensions and configurations of hoods, but I can't even remotely cover them in this forum. And it's unlikely any hobbyist would follow all those guidelines anyway.
A few words about the ducting: the square-to-round adapter shown on the website you referenced is a rather poor design, and will result in a higher SP drop than a tapered style of transition. In general, you'd be better served with something that is along these lines:
With regard to the double blower scenario, as has already been pointed out, it can be done, but there will be balancing problems to consider, particularly on the discharge side. I doubt it would be reasonable to design or cost effective (unless you already happen to have all that's required). I personally wouldn't opt for it in a hobby application.
Make-up air. Yes, this is a concern, especially with a larger (as in CFM) booth. But again as pointed out, the solution is as simple as opening a nearby window some to allow air to enter the room. And of course, it isn't generally recommended to have anything with an open flame in the area of a paint booth.
In my view, the largest "mistake" folks make is grossly underestimating the total static pressure that the blower will have to overcome to move the desired quantity of air. If you see a fan/blower rated at say, 300 CFM at 0" SP, that is a useless spec. It only states what a blower will do sitting on a bench with nothing connected to either end . . . in other words, it's a "free air" spec. Look at the specs for the Dayton blower you linked to. See how drastically the CFM delivered drops as the SP increases? Remember that EVERYTHING in the air stream adds to the resistance. EVERYTHING. Folks build a booth and sometimes they're lucky as it appears the booth is working great (and maybe it is). Others aren't so happy with the result. The trouble is, not many hobbyists have the instruments they would need to see if the blower is indeed delivering the air flow that they had hoped for. So we're more or less stuck with trying to design something as best we can, and the more we adhere to established guidelines, the more likely we are to have a satisfactory outcome.
Is it hard to do? Absolutely unless you are trained in ventilation design, or simply don't worry about the details. Eventually I plan to build my "ultimate" spray booth. Will it conform to industrial standards? Nope. But hopefully it will work to a point.